Isosorbide dinitrate-hydralazine combination therapy in African Americans with heart failure
نویسندگان
چکیده
منابع مشابه
Isosorbide dinitrate-hydralazine combination therapy in African Americans with heart failure
Despite significant improvement in therapy and management, heart failure remains a worrisome disease state that is especially problematic in special populations. African Americans suffer a disproportionately higher prevalence of heart failure when compared to other populations. It has been recently demonstrated that vasodilator therapy using the combination of isosorbide dinitrate (ISDN) and hy...
متن کاملCombination of isosorbide dinitrate and hydralazine in blacks with heart failure.
BACKGROUND We examined whether a fixed dose of both isosorbide dinitrate and hydralazine provides additional benefit in blacks with advanced heart failure, a subgroup previously noted to have a favorable response to this therapy. METHODS A total of 1050 black patients who had New York Heart Association class III or IV heart failure with dilated ventricles were randomly assigned to receive a f...
متن کاملCost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failure.
BACKGROUND Fixed-dose combination of isosorbide dinitrate/hydralazine (ISDN/HYD) improved clinical outcomes in the African-American Heart Failure Trial (A-HeFT). We assessed the resource use, costs of care, and cost-effectiveness of ISDN/HYD therapy in the A-HeFT trial population. METHODS AND RESULTS We obtained resource use data from A-HeFT, assigning costs through the use of US federal sour...
متن کاملPostural hypotension and tachycardia during hydralazine--isosorbide dinitrate therapy for chronic heart failure.
Supine and upright hemodynamic measurements were performed in 10 patients with chronic congestive heart failure, before and during vasodilator therapy with hydralazine and isosorbide dinitrate. This combination of drugs produced significant improvement in supine hemodynamic measurements, with the pulmonary capillary wedge pressure decreasing from 26 +/- 5 to 18 +/- 5 mm Hg (mean +/- SD, p less ...
متن کاملVasodilator treatment with isosorbide dinitrate and hydralazine in chronic heart failure.
Several reports have suggested that because isosorbide dinitrate and hydralazine have different and additive haemodynamic effects at rest in patients with chronic heart failure, these agents should be administered in combination. Some studies, however, indicate thay they are effective individually as well. Since most patients with heart failure are symptomatic only with activity, we examined th...
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ژورنال
عنوان ژورنال: Vascular Health and Risk Management
سال: 2006
ISSN: 1176-6344
DOI: 10.2147/vhrm.2006.2.4.423